The PERFORM Trial - Recruiting 12 NHS sites across UK
PERFORM is a Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (multimorbidity) project funded by NIHR Programme Grant for Applied Research for 5 years lead by Professor Sally Singh and Professor Rod Taylor.
We are looking at recruiting 12 NHS sites across UK for a full-scale randomised trial in people with multiple Long Term Conditions LTCs –ARE YOU INTERESTED?
PERFORM commenced in 2022 with 5 work packages and the overarching aim of work package 4 is to assess the clinical and cost-effectiveness of PERFORM in people with multiple LTCs. Specific objectives are:
- To assess the clinical effectiveness and cost-effectiveness of PERFORM to compared to usual in people with multiple LTCs not eligible for referral to a standard cardiac or pulmonary rehabilitation programme in a randomised clinical trial;
- To assess the clinical effectiveness and cost-effectiveness of the addition PERFORM to usual care compared to standard cardiac or pulmonary rehabilitation in people with multiple LTCs in a prospective cohort study.
- To refine programme theory and identify barriers and facilitators to future wide scale implementation and develop an implementation toolkit.
The study will use a comprehensive cohort study with concurrent multicentre superiority randomised RCT and prospective cohort study with embedded process and economic evaluations and internal pilot phase.
The study will be conducted at 12 NHS sites across the UK. Site selection will take into consideration the geographical variation in the prevalence of multiple LTCs and ethnicity and socioeconomic groups. Within sites, patients will be recruited using both primary and secondary care pathways. A sample size of 604 (302 per arm) participants provides 90% power to detect a minimum clinical important difference (MCID) in the primary outcome (EQ-5D-5L) of 0.05 at the 5% significance level.
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If you are interested or have any questions please email email@example.com